ARA-290, also known as cibinetide, is an investigational 11-amino-acid peptide designed to activate the body’s innate repair receptor (IRR).

It was developed from the tissue-protective region of erythropoietin (EPO), but unlike EPO, it is designed not to stimulate red blood cell production.

ARA-290 is being studied for its potential ability to reduce inflammation, protect injured tissues, and promote nerve repair.

Human clinical studies have been especially promising in small-fiber neuropathy.

Research has reported:

• Reduced neuropathic pain
• Improvement in corneal nerve fiber measures, suggesting regeneration of small nerve fibers
• A generally favorable safety and tolerability profile in the clinical studies performed to date

ARA-290 has also received FDA orphan-drug designation for sarcoidosis-related indications, but it remains investigational and is not FDA-approved for routine clinical use.

How ARA-290 May Work

ARA-290 activates the innate repair receptor, which is expressed in injured and inflamed tissues.

Activation of this receptor may help shift the body’s response from ongoing inflammation toward protection, recovery, and tissue repair.

Research suggests that ARA-290 may:

Reduce Inflammation

Decrease inflammatory signaling involving TNF-α, IL-1β, IL-6, and NF-κB.

Protect Cells from Injury

Activate signaling pathways such as PI3K/Akt, JAK/STAT, and other cellular survival mechanisms.

Support Nerve Repair

Promote the recovery of damaged small nerve fibers and reduce inflammation surrounding injured nerves.

Reduce Neuropathic Pain

Unlike conventional pain medications, ARA-290 may reduce pain by addressing inflammatory and nerve-injury mechanisms.

Promote Tissue Recovery

Preclinical research has investigated ARA-290 in models of diabetic complications, cardiovascular injury, traumatic brain injury, burns, metabolic dysfunction, and other forms of tissue damage.

Key Concept

ARA-290 is not merely an anti-inflammatory peptide.

It is being investigated as a tissue-protective and repair-signaling peptide that may assist the body in limiting injury, resolving inflammation, and regenerating damaged nerves.

For Research Purposes Only.

Not for human consumption.

Explore our other research compounds and nutritional supplements.

Scientific literature on ARA-290 is available through PubMed Central.

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